The Me-210 was developed to replace the Me-110 Zerstörer as a heavy fighter and ground-support plane. Dogged with early problems, the revised plane was renamed Me-410 (Hornisse, Hornet), apparently in an effort to distance it from the early flying problems.

Since the Me-210 and Me-410 were used primarily in areas under German control, examples only became available for Allied analysis relatively late in the war.